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Implantable batteryless device for on-demand and pulsatile insulin administration

Author

Listed:
  • Seung Ho Lee

    (Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University)

  • Young Bin Lee

    (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University)

  • Byung Hwi Kim

    (Seoul National University College of Medicine)

  • Cheol Lee

    (Seoul National University College of Medicine)

  • Young Min Cho

    (Seoul National University College of Medicine)

  • Se-Na Kim

    (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University)

  • Chun Gwon Park

    (Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University)

  • Yong-Chan Cho

    (Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University)

  • Young Bin Choy

    (Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University
    Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University
    Seoul National University College of Medicine)

Abstract

Many implantable systems have been designed for long-term, pulsatile delivery of insulin, but the lifetime of these devices is limited by the need for battery replacement and consequent replacement surgery. Here we propose a batteryless, fully implantable insulin pump that can be actuated by a magnetic field. The pump is prepared by simple-assembly of magnets and constituent units and comprises a drug reservoir and actuator equipped with a plunger and barrel, each assembled with a magnet. The plunger moves to noninvasively infuse insulin only when a magnetic field is applied on the exterior surface of the body. Here we show that the dose is easily controlled by varying the number of magnet applications. Also, pump implantation in diabetic rats results in profiles of insulin concentration and decreased blood glucose levels similar to those observed in rats treated with conventional subcutaneous insulin injections.

Suggested Citation

  • Seung Ho Lee & Young Bin Lee & Byung Hwi Kim & Cheol Lee & Young Min Cho & Se-Na Kim & Chun Gwon Park & Yong-Chan Cho & Young Bin Choy, 2017. "Implantable batteryless device for on-demand and pulsatile insulin administration," Nature Communications, Nature, vol. 8(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15032
    DOI: 10.1038/ncomms15032
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