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Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea

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  • Zhiqiang Li

    (The Affiliated Hospital of Qingdao University & The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University
    Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University
    Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University
    Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University)

  • Jianhua Chen

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University
    Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University
    Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine)

  • Ying Zhao

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

  • Yujiong Wang

    (Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University)

  • Jinrui Xu

    (Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University)

  • Jue Ji

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University)

  • Jingyi Shen

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University)

  • Weiping Zhang

    (Campus Health Center of Shanghai Jiao Tong University)

  • Zuosong Chen

    (Shanghai Jiao Tong University)

  • Qilin Sun

    (Shanghai Jiao Tong University)

  • Lijuan Mao

    (School of Physical Education and Coaching, Shanghai University of Sport)

  • Shulin Cheng

    (Shanghai Jiao Tong University)

  • Bo Yang

    (Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University)

  • Dongtao Zhang

    (Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University)

  • Yufeng Xu

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University)

  • Yingying Zhao

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University)

  • Danping Liu

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University)

  • Yinhuan Shen

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University)

  • Weijie Zhang

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University)

  • Changgui Li

    (Shandong Provincial Key Laboratory of Metabolic Disease & the Metabolic Disease Institute of Qingdao University)

  • Jiawei Shen

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University)

  • Yongyong Shi

    (The Affiliated Hospital of Qingdao University & The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University
    Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University
    Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University
    Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University)

Abstract

Primary dysmenorrhoea, defined as painful menstrual cramps in the absence of pelvic pathology, is a common problem in women of reproductive age. Its aetiology and pathophysiology remain largely unknown. Here we performed a two-stage genome-wide association study and subsequent replication study to identify genetic factors associated with primary dysmenorrhoea in a total of 6,770 Chinese individuals. Our analysis provided evidence of a significant (P

Suggested Citation

  • Zhiqiang Li & Jianhua Chen & Ying Zhao & Yujiong Wang & Jinrui Xu & Jue Ji & Jingyi Shen & Weiping Zhang & Zuosong Chen & Qilin Sun & Lijuan Mao & Shulin Cheng & Bo Yang & Dongtao Zhang & Yufeng Xu & , 2017. "Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea," Nature Communications, Nature, vol. 8(1), pages 1-7, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14900
    DOI: 10.1038/ncomms14900
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