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Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

Author

Listed:
  • Paul Yeh

    (Peter MacCallum Cancer Centre
    Peter MacCallum Cancer Centre
    University of Melbourne)

  • Tane Hunter

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Devbarna Sinha

    (Peter MacCallum Cancer Centre)

  • Sarah Ftouni

    (Peter MacCallum Cancer Centre)

  • Elise Wallach

    (Peter MacCallum Cancer Centre)

  • Damian Jiang

    (Peter MacCallum Cancer Centre)

  • Yih-Chih Chan

    (Peter MacCallum Cancer Centre)

  • Stephen Q. Wong

    (Peter MacCallum Cancer Centre)

  • Maria Joao Silva

    (Peter MacCallum Cancer Centre)

  • Ravikiran Vedururu

    (Peter MacCallum Cancer Centre)

  • Kenneth Doig

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Enid Lam

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Gisela Mir Arnau

    (Peter MacCallum Cancer Centre)

  • Timothy Semple

    (Peter MacCallum Cancer Centre)

  • Meaghan Wall

    (Victorian Cancer Cytogenetics Service, St Vincent’s Hospital
    St Vincent’s Hospital, University of Melbourne)

  • Andjelija Zivanovic

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Rishu Agarwal

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Pasquale Petrone

    (Peter MacCallum Cancer Centre)

  • Kate Jones

    (Peter MacCallum Cancer Centre)

  • David Westerman

    (Peter MacCallum Cancer Centre
    Peter MacCallum Cancer Centre
    University of Melbourne)

  • Piers Blombery

    (Peter MacCallum Cancer Centre
    Peter MacCallum Cancer Centre)

  • John F. Seymour

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Anthony T. Papenfuss

    (Peter MacCallum Cancer Centre
    University of Melbourne
    Walter and Eliza Hall Institute of Medical Research)

  • Mark A. Dawson

    (Peter MacCallum Cancer Centre
    Peter MacCallum Cancer Centre
    University of Melbourne
    Centre for Cancer Research, University of Melbourne)

  • Constantine S. Tam

    (Peter MacCallum Cancer Centre
    University of Melbourne
    St Vincent’s Hospital, University of Melbourne
    St Vincent’s Hospital)

  • Sarah-Jane Dawson

    (Peter MacCallum Cancer Centre
    Peter MacCallum Cancer Centre
    University of Melbourne
    Centre for Cancer Research, University of Melbourne)

Abstract

Several novel therapeutics are poised to change the natural history of chronic lymphocytic leukaemia (CLL) and the increasing use of these therapies has highlighted limitations of traditional disease monitoring methods. Here we demonstrate that circulating tumour DNA (ctDNA) is readily detectable in patients with CLL. Importantly, ctDNA does not simply mirror the genomic information contained within circulating malignant lymphocytes but instead parallels changes across different disease compartments following treatment with novel therapies. Serial ctDNA analysis allows clonal dynamics to be monitored over time and identifies the emergence of genomic changes associated with Richter’s syndrome (RS). In addition to conventional disease monitoring, ctDNA provides a unique opportunity for non-invasive serial analysis of CLL for molecular disease monitoring.

Suggested Citation

  • Paul Yeh & Tane Hunter & Devbarna Sinha & Sarah Ftouni & Elise Wallach & Damian Jiang & Yih-Chih Chan & Stephen Q. Wong & Maria Joao Silva & Ravikiran Vedururu & Kenneth Doig & Enid Lam & Gisela Mir A, 2017. "Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia," Nature Communications, Nature, vol. 8(1), pages 1-7, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14756
    DOI: 10.1038/ncomms14756
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