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Allograft inflammatory factor 1 is a regulator of transcytosis in M cells

Author

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  • Sari Kishikawa

    (The Institute of Medical Science, The University of Tokyo
    Section of Oral and Maxillofacial Oncology, Faculty of Dental Science, Kyushu University)

  • Shintaro Sato

    (The Institute of Medical Science, The University of Tokyo
    International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
    Mucosal Vaccine Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University)

  • Satoshi Kaneto

    (The Institute of Medical Science, The University of Tokyo)

  • Shigeo Uchino

    (National Institute of Neuroscience
    Present address: Department of Biosciences, School of Science and Engineering, Teikyo University, Tochigi 320-8551, Japan)

  • Shinichi Kohsaka

    (National Institute of Neuroscience)

  • Seiji Nakamura

    (Section of Oral and Maxillofacial Oncology, Faculty of Dental Science, Kyushu University)

  • Hiroshi Kiyono

    (The Institute of Medical Science, The University of Tokyo
    International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
    Graduate School of Medicine, Chiba University)

Abstract

M cells in follicle-associated epithelium (FAE) are specialized antigen-sampling cells that take up intestinal luminal antigens. Transcription factor Spi-B regulates M-cell maturation, but the molecules that promote transcytosis within M cells are not fully identified. Here we show that mouse allograft inflammatory factor 1 (Aif1) is expressed by M cells and contributes to M-cell transcytosis. FAE in Aif1−/− mice has suppressed uptake of particles and commensal bacteria, compared with wild-type mice. Translocation of Yersinia enterocolitica, but not of Salmonella enterica serovar Typhimurium, leading to the generation of antigen-specific IgA antibodies, is also diminished in Aif1-deficient mice. Although β1 integrin, which acts as a receptor for Y. enterocolitica via invasin protein, is expressed on the apical surface membranes of M cells, its active form is rarely found in Aif1−/− mice. These findings show that Aif1 is important for bacterial and particle transcytosis in M cells.

Suggested Citation

  • Sari Kishikawa & Shintaro Sato & Satoshi Kaneto & Shigeo Uchino & Shinichi Kohsaka & Seiji Nakamura & Hiroshi Kiyono, 2017. "Allograft inflammatory factor 1 is a regulator of transcytosis in M cells," Nature Communications, Nature, vol. 8(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14509
    DOI: 10.1038/ncomms14509
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