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Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Author

Listed:
  • Nikaïa Smith

    (CNRS UMR-8601, Université Paris Descartes, CICB
    Team Chemistry & Biology, Modeling & Immunology for Therapy, CBMIT)

  • Nicolas Pietrancosta

    (CNRS UMR-8601, Université Paris Descartes, CICB
    Team Chemistry & Biology, Modeling & Immunology for Therapy, CBMIT)

  • Sophia Davidson

    (Immunoregulation Laboratory, Francis Crick Institute
    Present address: Division of Chemical Biology and Division of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia, Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia)

  • Jacques Dutrieux

    (INSERM UMR-S 1124, Université Paris Descartes)

  • Lise Chauveau

    (Institut Pasteur, Virus & Immunity Unit)

  • Pasquale Cutolo

    (Inflammation Chimiokines et Immunopathologie, INSERM, Faculté de médecine—Université Paris-Sud, Université Paris-Saclay)

  • Michel Dy

    (CNRS UMR-8147, Hôpital Necker)

  • Daniel Scott-Algara

    (Institut Pasteur, Unité de Régulation des Infections Rétrovirales)

  • Bénédicte Manoury

    (INSERM U1151, CNRS8253, Université Paris Descartes, Hôpital Necker)

  • Onofrio Zirafi

    (Institute of Molecular Virology, Ulm University Medical Center)

  • Isabelle McCort-Tranchepain

    (CNRS UMR-8601, Université Paris Descartes, CICB)

  • Thierry Durroux

    (Institut de Génomique Fonctionnelle, CNRS UMR5203, INSERM U661, Université de Montpellier (IFR3))

  • Françoise Bachelerie

    (Inflammation Chimiokines et Immunopathologie, INSERM, Faculté de médecine—Université Paris-Sud, Université Paris-Saclay)

  • Olivier Schwartz

    (Institut Pasteur, Virus & Immunity Unit)

  • Jan Münch

    (Institute of Molecular Virology, Ulm University Medical Center)

  • Andreas Wack

    (Immunoregulation Laboratory, Francis Crick Institute)

  • Sébastien Nisole

    (INSERM UMR-S 1124, Université Paris Descartes)

  • Jean-Philippe Herbeuval

    (CNRS UMR-8601, Université Paris Descartes, CICB
    Team Chemistry & Biology, Modeling & Immunology for Therapy, CBMIT)

Abstract

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential ‘on-off’ switch of pDC activity with therapeutic potential.

Suggested Citation

  • Nikaïa Smith & Nicolas Pietrancosta & Sophia Davidson & Jacques Dutrieux & Lise Chauveau & Pasquale Cutolo & Michel Dy & Daniel Scott-Algara & Bénédicte Manoury & Onofrio Zirafi & Isabelle McCort-Tran, 2017. "Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement," Nature Communications, Nature, vol. 8(1), pages 1-13, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14253
    DOI: 10.1038/ncomms14253
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