IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms14170.html
   My bibliography  Save this article

Divergent prion strain evolution driven by PrPC expression level in transgenic mice

Author

Listed:
  • Annick Le Dur

    (Virologie Immunologie Moléculaires (VIM), INRA, Université Paris-Saclay)

  • Thanh Lan Laï

    (Virologie Immunologie Moléculaires (VIM), INRA, Université Paris-Saclay)

  • Marie-George Stinnakre

    (Génétique Animale et Biologie Intégrative (GABI), INRA, AgroParisTech, Université Paris-Saclay)

  • Aude Laisné

    (Virologie Immunologie Moléculaires (VIM), INRA, Université Paris-Saclay)

  • Nathalie Chenais

    (Génétique Animale et Biologie Intégrative (GABI), INRA, AgroParisTech, Université Paris-Saclay)

  • Sabine Rakotobe

    (Virologie Immunologie Moléculaires (VIM), INRA, Université Paris-Saclay)

  • Bruno Passet

    (Génétique Animale et Biologie Intégrative (GABI), INRA, AgroParisTech, Université Paris-Saclay)

  • Fabienne Reine

    (Virologie Immunologie Moléculaires (VIM), INRA, Université Paris-Saclay)

  • Solange Soulier

    (Génétique Animale et Biologie Intégrative (GABI), INRA, AgroParisTech, Université Paris-Saclay)

  • Laetitia Herzog

    (Virologie Immunologie Moléculaires (VIM), INRA, Université Paris-Saclay)

  • Gaëlle Tilly

    (Génétique Animale et Biologie Intégrative (GABI), INRA, AgroParisTech, Université Paris-Saclay)

  • Human Rézaei

    (Virologie Immunologie Moléculaires (VIM), INRA, Université Paris-Saclay)

  • Vincent Béringue

    (Virologie Immunologie Moléculaires (VIM), INRA, Université Paris-Saclay)

  • Jean-Luc Vilotte

    (Génétique Animale et Biologie Intégrative (GABI), INRA, AgroParisTech, Université Paris-Saclay)

  • Hubert Laude

    (Virologie Immunologie Moléculaires (VIM), INRA, Université Paris-Saclay)

Abstract

Prions induce a fatal neurodegenerative disease in infected host brain based on the refolding and aggregation of the host-encoded prion protein PrPC into PrPSc. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Constrained interactions between PrPC and different PrPSc strains can in turn lead to certain PrPSc (sub)populations being selected for cross-species transmission, or even produce mutation-like events. By contrast, prion strains are generally conserved when transmitted within the same species, or to transgenic mice expressing homologous PrPC. Here, we compare the strain properties of a representative sheep scrapie isolate transmitted to a panel of transgenic mouse lines expressing varying levels of homologous PrPC. While breeding true in mice expressing PrPC at near physiological levels, scrapie prions evolve consistently towards different strain components in mice beyond a certain threshold of PrPC overexpression. Our results support the view that PrPC gene dosage can influence prion evolution on homotypic transmission.

Suggested Citation

  • Annick Le Dur & Thanh Lan Laï & Marie-George Stinnakre & Aude Laisné & Nathalie Chenais & Sabine Rakotobe & Bruno Passet & Fabienne Reine & Solange Soulier & Laetitia Herzog & Gaëlle Tilly & Human Réz, 2017. "Divergent prion strain evolution driven by PrPC expression level in transgenic mice," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14170
    DOI: 10.1038/ncomms14170
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms14170
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms14170?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14170. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.