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Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment

Author

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  • Xia Li

    (World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS))

  • Xiupeng Wang

    (Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST))

  • Jun Zhang

    (World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS)
    School of Materials Science and Engineering, Hebei Key Laboratory of Boron Nitride Micro and Nano Materials, Hebei University of Technology)

  • Nobutaka Hanagata

    (Nanotechnology Innovation Station, National Institute for Materials Science (NIMS))

  • Xuebin Wang

    (World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS))

  • Qunhong Weng

    (World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS))

  • Atsuo Ito

    (Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST))

  • Yoshio Bando

    (World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS))

  • Dmitri Golberg

    (World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS))

Abstract

High global incidence of prostate cancer has led to a focus on prevention and treatment strategies to reduce the impact of this disease in public health. Boron compounds are increasingly recognized as preventative and chemotherapeutic agents. However, systemic administration of soluble boron compounds is hampered by their short half-life and low effectiveness. Here we report on hollow boron nitride (BN) spheres with controlled crystallinity and boron release that decrease cell viability and increase prostate cancer cell apoptosis. In vivo experiments on subcutaneous tumour mouse models treated with BN spheres demonstrated significant suppression of tumour growth. An orthotopic tumour growth model was also utilized and further confirmed the in vivo anti-cancer efficacy of BN spheres. Moreover, the administration of hollow BN spheres with paclitaxel leads to synergetic effects in the suppression of tumour growth. The work demonstrates that hollow BN spheres may function as a new agent for prostate cancer treatment.

Suggested Citation

  • Xia Li & Xiupeng Wang & Jun Zhang & Nobutaka Hanagata & Xuebin Wang & Qunhong Weng & Atsuo Ito & Yoshio Bando & Dmitri Golberg, 2017. "Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment," Nature Communications, Nature, vol. 8(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms13936
    DOI: 10.1038/ncomms13936
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