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Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control

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  • Glenn Dallérac

    (Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay
    Present address: Collège de France, CIRB, CNRS UMR 7241, INSERM U1050, Paris F-75005, France)

  • Michael Graupner

    (Center for Neural Science, New York University
    Present address: Laboratoire de Physiologie Cérébrale, UMR 8118, Université Paris Descartes, Paris 75006, France)

  • Jeroen Knippenberg

    (Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay)

  • Raquel Chacon Ruiz Martinez

    (Laboratory of Neuromodulation, Teaching and Research Institute, Hospital Sirio Libanes, Rua Professor Daher Cutait, 69)

  • Tatiane Ferreira Tavares

    (Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay)

  • Lucille Tallot

    (Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay)

  • Nicole El Massioui

    (Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay)

  • Anna Verschueren

    (Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay)

  • Sophie Höhn

    (Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay)

  • Julie Boulanger Bertolus

    (Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay
    École Normale Supérieure)

  • Alex Reyes

    (Center for Neural Science, New York University)

  • Joseph E. LeDoux

    (Center for Neural Science, New York University
    Nathan Kline Institute for Psychiatric Research)

  • Glenn E. Schafe

    (Hunter College)

  • Lorenzo Diaz-Mataix

    (Center for Neural Science, New York University)

  • Valérie Doyère

    (Institut des Neurosciences Paris-Saclay (Neuro-PSI), UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay)

Abstract

Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS–US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3–6 Hz). Strikingly, we also show that a change to the CS–US time interval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amygdala. Collectively, this study reveals physiological correlates of plasticity mechanisms of interval timing that take place in the striatum and are regulated by the amygdala.

Suggested Citation

  • Glenn Dallérac & Michael Graupner & Jeroen Knippenberg & Raquel Chacon Ruiz Martinez & Tatiane Ferreira Tavares & Lucille Tallot & Nicole El Massioui & Anna Verschueren & Sophie Höhn & Julie Boulanger, 2017. "Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control," Nature Communications, Nature, vol. 8(1), pages 1-14, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms13920
    DOI: 10.1038/ncomms13920
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