IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms13882.html
   My bibliography  Save this article

Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2

Author

Listed:
  • Chia-Lin Chen

    (Keck School of Medicine, University of Southern California)

  • Jeffrey Y. Huang

    (Keck School of Medicine, University of Southern California)

  • Chun-Hsiang Wang

    (Keck School of Medicine, University of Southern California)

  • Stanley M Tahara

    (Keck School of Medicine, University of Southern California)

  • Lin Zhou

    (Keck School of Medicine, University of Southern California)

  • Yasuteru Kondo

    (Keck School of Medicine, University of Southern California)

  • Joel Schechter

    (Keck School of Medicine, University of Southern California)

  • Lishan Su

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill)

  • Michael M C. Lai

    (Keck School of Medicine, University of Southern California
    Institute of Molecular Biology, Academia Sinica)

  • Takaji Wakita

    (National Institute of Infectious Diseases)

  • François-Loïc Cosset

    (International Center for Infectiology Research, Team EVIR)

  • Jae U Jung

    (Keck School of Medicine, University of Southern California)

  • Keigo Machida

    (Keck School of Medicine, University of Southern California)

Abstract

B-cell infection by hepatitis C virus (HCV) has been a controversial topic. To examine whether HCV has a genetically determined lymphotropism through a co-receptor specific for the infection by lymphotropic HCV, we established an infectious clone and chimeric virus of hepatotropic and lymphotropic HCV strains derived from an HCV-positive B-cell lymphoma. The viral envelope and 5′-UTR sequences of the lymphotropic HCV strain were responsible for the lymphotropism. Silencing of the virus sensor, RIGI, or overexpression of microRNA-122 promoted persistent viral replication in B cells. By cDNA library screening, we identified an immune cell-specific, co-stimulatory receptor B7.2 (CD86) as a co-receptor of lymphotropic HCV. Infection of B cells by HCV inhibited the recall reaction to antigen stimulation. Together, a co-receptor B7.2 enabled lymphotropic HCV to infect memory B cells, leading to inhibition of memory B-cell function and persistent HCV infection in HCV-infected hosts.

Suggested Citation

  • Chia-Lin Chen & Jeffrey Y. Huang & Chun-Hsiang Wang & Stanley M Tahara & Lin Zhou & Yasuteru Kondo & Joel Schechter & Lishan Su & Michael M C. Lai & Takaji Wakita & François-Loïc Cosset & Jae U Jung &, 2017. "Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2," Nature Communications, Nature, vol. 8(1), pages 1-17, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms13882
    DOI: 10.1038/ncomms13882
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms13882
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms13882?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms13882. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.