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Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome

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  • Junnan Tang

    (The First Affiliated Hospital of Zhengzhou University
    North Carolina State University
    University of North Carolina at Chapel Hill & North Carolina State University, Chapel Hill and Raleigh
    Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University)

  • Deliang Shen

    (The First Affiliated Hospital of Zhengzhou University
    Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University)

  • Thomas George Caranasos

    (University of North Carolina at Chapel Hill)

  • Zegen Wang

    (The Cyrus Tang Hematology Center, Soochow University)

  • Adam C. Vandergriff

    (North Carolina State University
    University of North Carolina at Chapel Hill & North Carolina State University, Chapel Hill and Raleigh)

  • Tyler A. Allen

    (North Carolina State University
    University of North Carolina at Chapel Hill & North Carolina State University, Chapel Hill and Raleigh)

  • Michael Taylor Hensley

    (North Carolina State University
    University of North Carolina at Chapel Hill & North Carolina State University, Chapel Hill and Raleigh)

  • Phuong-Uyen Dinh

    (North Carolina State University
    University of North Carolina at Chapel Hill & North Carolina State University, Chapel Hill and Raleigh)

  • Jhon Cores

    (North Carolina State University
    University of North Carolina at Chapel Hill & North Carolina State University, Chapel Hill and Raleigh)

  • Tao-Sheng Li

    (Atomic Bomb Disease Institute, Nagasaki University)

  • Jinying Zhang

    (The First Affiliated Hospital of Zhengzhou University
    Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University)

  • Quancheng Kan

    (The First Affiliated Hospital of Zhengzhou University)

  • Ke Cheng

    (North Carolina State University
    University of North Carolina at Chapel Hill & North Carolina State University, Chapel Hill and Raleigh
    The Cyrus Tang Hematology Center, Soochow University
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill)

Abstract

Stem cell therapy represents a promising strategy in regenerative medicine. However, cells need to be carefully preserved and processed before usage. In addition, cell transplantation carries immunogenicity and/or tumourigenicity risks. Mounting lines of evidence indicate that stem cells exert their beneficial effects mainly through secretion (of regenerative factors) and membrane-based cell–cell interaction with the injured cells. Here, we fabricate a synthetic cell-mimicking microparticle (CMMP) that recapitulates stem cell functions in tissue repair. CMMPs carry similar secreted proteins and membranes as genuine cardiac stem cells do. In a mouse model of myocardial infarction, injection of CMMPs leads to the preservation of viable myocardium and augmentation of cardiac functions similar to cardiac stem cell therapy. CMMPs (derived from human cells) do not stimulate T-cell infiltration in immuno-competent mice. In conclusion, CMMPs act as ‘synthetic stem cells’ which mimic the paracrine and biointerfacing activities of natural stem cells in therapeutic cardiac regeneration.

Suggested Citation

  • Junnan Tang & Deliang Shen & Thomas George Caranasos & Zegen Wang & Adam C. Vandergriff & Tyler A. Allen & Michael Taylor Hensley & Phuong-Uyen Dinh & Jhon Cores & Tao-Sheng Li & Jinying Zhang & Quanc, 2017. "Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome," Nature Communications, Nature, vol. 8(1), pages 1-9, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms13724
    DOI: 10.1038/ncomms13724
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