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Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014

Author

Listed:
  • Martin C. W. Chan

    (Faculty of Medicine, 1/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Chinese University of Hong Kong)

  • Nelson Lee

    (Faculty of Medicine, 9/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Chinese University of Hong Kong)

  • Tin-Nok Hung

    (Faculty of Medicine, 1/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Chinese University of Hong Kong)

  • Kirsty Kwok

    (Faculty of Medicine, 1/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Chinese University of Hong Kong)

  • Kelton Cheung

    (Faculty of Medicine, 1/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Chinese University of Hong Kong)

  • Edith K. Y. Tin

    (Faculty of Medicine, 1/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Chinese University of Hong Kong)

  • Raymond W. M. Lai

    (Faculty of Medicine, 1/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Chinese University of Hong Kong)

  • E. Anthony S. Nelson

    (Faculty of Medicine, 6/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Chinese University of Hong Kong)

  • Ting F. Leung

    (Faculty of Medicine, 6/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Chinese University of Hong Kong)

  • Paul K. S. Chan

    (Faculty of Medicine, 1/F Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Chinese University of Hong Kong)

Abstract

Norovirus genogroup II genotype 4 (GII.4) has been the predominant cause of viral gastroenteritis since 1996. Here we show that during the winter of 2014–2015, an emergent variant of a previously rare norovirus GII.17 genotype, Kawasaki 2014, predominated in Hong Kong and outcompeted contemporary GII.4 Sydney 2012 in hospitalized cases. GII.17 cases were significantly older than GII.4 cases. Root-to-tip and Bayesian BEAST analyses estimate GII.17 viral protein 1 (VP1) evolves one order of magnitude faster than GII.4 VP1. Residue substitutions and insertion occur in four of five inferred antigenic epitopes, suggesting immune evasion. Sequential GII.4-GII.17 infections are noted, implicating a lack of cross-protection. Virus bound to saliva of secretor histo-blood groups A, B and O, indicating broad susceptibility. This fast-evolving, broadly recognizing and probably immune-escaped emergent GII.17 variant causes severe gastroenteritis and hospitalization across all age groups, including populations who were previously less vulnerable to GII.4 variants; therefore, the global spread of GII.17 Kawasaki 2014 needs to be monitored.

Suggested Citation

  • Martin C. W. Chan & Nelson Lee & Tin-Nok Hung & Kirsty Kwok & Kelton Cheung & Edith K. Y. Tin & Raymond W. M. Lai & E. Anthony S. Nelson & Ting F. Leung & Paul K. S. Chan, 2015. "Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms10061
    DOI: 10.1038/ncomms10061
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    Cited by:

    1. Ryota Matsuyama & Fuminari Miura & Hiroshi Nishiura, 2017. "The transmissibility of noroviruses: Statistical modeling of outbreak events with known route of transmission in Japan," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-16, March.

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